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Arthritis Gout Treatment and New Gout Drugs and Pegloticase

Arthritis Gout Treatment and New Gout Drugs and Pegloticase
by asia » Tue Jul 26, 2016 10:54 pm

Arthritis Gout Treatment - New Gout Drugs - Pegloticase Continues Its Hopeful Path

May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development. :oops:

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

<strong>TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS </strong> Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe. :D.

<strong>SIDE EFFECTS </strong> Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. Gout in women cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.


This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. Isn't it wonderful that we can now access information about anything, including Excess Uric Acid form the Internet without the hassle of going through books and magazines for matter!

Other Patient Groups There Were Reductions in Attacks and Improvement in Tophi Reduction

Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. Coordinating matter regarding to Normal Uric Acid took a lot of time. However, with the progress of time, we not only gathered more matter, we also learnt more about Normal Uric Acid.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. The more you read about Gout Drugs, the more you get to understand the meaning of it. So if you read this article and other related articles, you are sure to get the required amount of matter for yourself :roll:

Has Been Having a Decent Degree of Success

<strong>Elimination of gout attacks </strong>In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial. :D.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels. Learning about things is what we are living here for now. So try to get to know as much about everything, including Normal Uric Acid whenever possible.

Has Taken a Very Long Time for a Major New Gout Drug to be Developed and Approved

Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

Generally, Febuxostat Has Been More Effective When UA Levels are Below

0 mg/dL (595 mmol/mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages. Our dreams of writing a lengthy article on Allopurinol 300 Mg has finally materialized Through this article on Allopurinol 300 Mg. however, only if you acknowledge its use, will we feel gratitude for writing it! :roll:

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 0 mg/dL (357 mmol/mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the dealing with arthritis in the workplace countries consider its approval. We found it rather unbelievable to find out that there is so much to learn on Uric Acid Production! Wonder if you could believe it after going through it!

This Approval Applies Only to EU Countries

Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country. We have to be very flexible when talking to children about Www Gout. They seem to interpret things in a different way from the way we see things!


Will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you. Nothing abusive about Purine Diet have been intentionally added here. Whatever it is that we have added, is all informative and productive to you.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment. After many hopeless endeavors to produce something worthwhile on Allopurinol 300 Mg, this is what we have come up with. We are very hopeful about this!

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 0 mg/dL level more quickly, than did those on Allopurinol. When a child shows a flicker of understanding when talking about Gout Sufferers, we feel that the objective of the meaning of Gout Sufferers being spread, being achieved.


You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

And It May Cause Side Effects of Course

See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids. People have an inclination of bragging on the knowledge they have on any particular project. However, we don't want to brag on what we know on Www Gout, so long as it proves useful to you, we are happy.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.


5. Fruity Therapy- Water soluble fiber is very beneficial to your health. There are at least 20 reasons to be eating fruits and veggies. A couple reasons are that some fruits actually neutralize uric acid and flush uric acid. Fiber is notorious for flushing the body and uric acid is excluded from the flush. We did not write too elaborate an article on Gout Symptoms as it would be then difficult for the common man to read it. We have written this article in such a way that everyone will be able to read and understand it!

And in Most Cases, Doctors Do Not Have an Answer for Treating the Gout Causing Uric Acid

They simply provide patients with pain relieving NSAIDs. Self-praise is no praise. So we don't want to praise ourselves on the effort put in writing on Gout Sufferers. instead, we would like to hear your praise after reading it!

4. Vitamin Therapy- Research studies have shown that a deficiency in vitamins such as A, B5 and E are serious factors that can lead to the formation and advancement of gout symptoms. You should get a quality multi-vitamin and also supplement individual vitamins if needed. Reading all this about Gout Health is sure to help you get a better understanding of Gout Health. So make full use of the information we have provided here.


2. Your weight- Do you know what your BMI is? Checking your body mass index can allow you to see what your ideal weight is. You should always try to be within 30 lbs. of your ideal weight. Obesity increases the risk of uric acid. :)


3. Flush Uric Acid- You can naturally flush uric acid with water. Go and buy a Nalgene water bottle and begin measuring how much water you drink per day. You should be drinking half your body weight in ounces per day. Thinking of what to do upon reading this article on Gout Treatment? Well you can very well use the information constructively by imparting it to others. :shock:


Unfortunately, millions of gout sufferers continue to see their doctor about the arthritis condition that usually affects the big toe. And after an expensive doctor visit and a more expensive prescription of pain killers, you still don't have a cure for gout but only a treatment for the pain.